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Associate Professor
Name: Charmaine Arderne
Location: C2 Lab 215 Auckland Park Kingsway Campus
Staff Members
Contact Details:
Tel: +27 (0) 11 559 2360
Email: carderne@uj.ac.za
Curriculum Vitae Charmaine ArderneAbout Prof Charmaine Arderne
POSTAL ADDRESS:
Department of Chemical Sciences
University of Johannesburg
PO Box 524
AUCKLAND PARK 2006
South Africa
PHYSICAL ADDRESS:
Room: C2LAB 215
Department of Chemical Sciences
University of Johannesburg
Ditton Road
AUCKLAND PARK
South Africa
ACADEMIC QUALIFICATIONS:
PhD (Physical Chemistry), University of Johannesburg, 2011
RESEARCH INTERESTS:
I have completed my PhD in Physical Chemistry with Prof. Gert Kruger in January 2011. Research that was carried out involved the crystallographic study of long-chained materials. Focus was on the structural characteristics and physical properties of long-chained n-alkyl diammonium salts as they are precursors to layered inorganic-organic perovskite-type hybrids; they are bidentate ligands in transition metal complexes that have applications in propellants, explosives and pyrotechnic compositions; they have structure directing properties in the synthesis of several zeolites and many new novel nanomaterials; and many have biological applications. Funding for the project came from the NRF Thuthuka programme and the University of Johannesburg.
I am currently a member of the Research Centre for Synthesis and Catalysis and am working on the following projects:
Metal induced cleavage of peptide and amide bonds using Co(III) amine and Co(III) amino acid complexes and their investigation as urease mimics.
This project is an experimental study of the synthesis, analysis and reaction of Cobalt(III) amine and Cobalt(III) amino acids complexes with urea-based materials to establish if cleavage of the amide and peptide bonds is successful. Also, the research is undertaken to determine and understand the mechanistic steps of these reactions and to conclusively determine if the cleavage occurs hydrolytically or by oxidative means and to establish if the metal complexes will function effectively as urease mimics. The broader scope of this project is in the field of biocatalysis. This project was awarded an NRF Thuthuka Award for funding 2016 – 2018 and again from 2019 – 2021. I have a small research group consisting of one MSc student; two PhD students and one Undergraduate Research Assistant, learning the relevant skills associated with this field of study. Recently, a postdoctoral fellow has joined the research group (Dr Bhawna Uprety) who will drive the project in a few different directions, and she will also assist the current students with their research in this area. This work is a joint collaborative effort between me and the project initiator Prof Ivan Bernal (retired Professor at University of Houston, Texas, USA) and Prof Demetrius Levendis (University of the Witwatersrand). This is my primary research interest, and my research group is the Biocatalysis and Structural Chemistry Research Group
Structural investigation of natural products and their application in the field of medicinal chemistry.
This project is a structural study of several natural and synthetic materials that are tested for medicinal properties. The research undertaken involves the structural characterization using X-ray crystallography of many active ingredients that have been extracted from medicinal plants. Their structural characteristics are being investigated to understand their medicinal activity. This project is a collaboration with a colleague in the Department of Chemical Sciences on the DFC campus (with Prof Derek Ndinteh, who is the project leader) and my role in the project is solely as a crystallographer. I also have an expert crystallographer collaborating on this project in the person of Prof Ilia Guzei (Visiting Professor, University of Johannesburg; University of Wisconsin – Madison) who assists with the solution of difficult crystal structures of the materials that are extracted from the plant material under investigation.
RESEARCH COLLABORATIONS.
Prof Derek Ndinteh – University of Johannesburg (DFC Campus), RSA
Prof Ilia Guzei – University of Wisconsin, Madison, United States of America
Prof Ivan Bernal – University of Houston, Texas, United States of America
Prof Demetrius Levendis – University of the Witwatersrand, Johannesburg, RSA
Prof Damian Onwudiwer – North West University (Mafikeng Campus), RSA
RESEARCH PUBLICATIONS:
Nandi, D., Perla, V. K., Ghosh, S. K., Arderne, C., Mallick, K. 2020, Copper-azide nanoparticle: a catalyst-cum-reagent for the designing of 5-alkynyl-1,4-disubstituted triazoles., Scientific Reports. vol 10, issue 1, 1 – 10 https://doi.org/10.1038/s41598-020-74018-8
Arderne, C., Batchelor, K. F., Uprety, B., Chandran, R., Abrahamse, H. 2020, Reactivity trends of cobalt(III) complexes towards various amino acids based on the properties of the amino acid alkyl chains., Acta. Cryst. Section C, vol 76, issue 7, 663 – 672.
Talla, E., Fotsing, M.C.D., Ismaila, M.B., Tata, C. M., Ikhile, M. I., Rhyman, L., Arderne, C., Niemann, N., Ramasami, P., Ndinteh, D. T. 2020, .Density functional theory studies of Hypaphorine from Erythrina mildbraedii and Erythrina addisoniae: structural and biological properties., SN Appl. Sci. vol. 2, issue 3, 1 – 12. https://doi.org/10.1007/s42452-020-2228-z
Uprety, B., & Arderne, C. 2019, The crystal structure of the zwitterionic co-crystal of 2,4-dichloro-6-{[(3-hydroxypropyl)ammonio]-methyl}phenolate and 2,4-dichlorophenol, Acta. Cryst. Section E, vol. 75, 1452 – 1455.
Peleyeju, G. B., Emmanuel, T., Tata, C. M., Fotsing, M. C. D., Niemann, N., Rhyman, L., Arderne, C., Ndinteh, D. T., Ramasami, P. 2019, Crystal structure and antibacterial activity of Scandenone (warangalone) from Erythrina plants, Journal of Molecular Structure, vol. 1191, 43 – 51.
Bobinihi, F. F., Onwudiwe, D. C., Ekennia, A. C., Okpareke, O. C., Arderne, C. & Lane, J. R. 2019, Group 10 metal complexes of dithiocarbamates derived from primary anilines: Synthesis, characterization, computational and antimicrobial studies, Polyhedron, vol. 158, 296 – 310.
Roodt, G. T., Uprety, B., Levendis, D. C. & Arderne, C. 2019, Energetic propane-1,3-diaminium and butane-1,4-diaminium salts of N,N′-dinitroethylenediazanide: syntheses, crystal structures and thermal properties, , Acta. Cryst. Section C, vol. 75, 54 – 60.
Uprety, B., Arderne, C., & Bernal, I. 2018, Catalytic Cleavage of the Amide Bond in Urea Using a Cobalt(III) Amino-Based Complex, Euro. J. Inorg. Chem., 5058 – 5067.
Fonkui, T. Y., Ikhile, M. I., Muganza, F. M., Fotsing, M. C. D., Arderne, C., Siwe-Noundou, X., Krause, R. W. M., Ndinteh, D. T. & Njobeh, P. B. 2018, Synthesis, characterization and biological applications of novel Schiff bases of 2-(trifluoromethoxy)aniline, J. Chin. Pharm. Sci.,vol. 27, no. 5, 307 – 323.
Ikhile, M. I., Fotsing, M. C. D., Arderne, C., Ngila, J. C. & Ndinteh, D. T. 2017, Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde, J. Chin. Pharm. Sci., vol. 16, no. 12, 858 – 871.
Vinokur, A. I., White, P. B., Fotsing, M. T., Arderne, C., Ndinteh, D. T., Vestling, M. M. & Guzei, I. A. 2017, Deciphering composition and connectivity of a natural product with the assistance of MS and 2D NMR, Acta Cryst. Section C, vol. 73, 994 – 1002.
Onwudiwe, D. C., Hrubaru, M., Hosten, E. C., Arderne, C. 2017, Bis(μ-N,N-diallyldithiocarbam-ato)bis[(N,N-diallyldithiocarbamato)cadmium], Acta Cryst. Section E, vol. 73, no. 9, 1353 – 1356.
Arderne, C., Batchelor, K. F. 2017, The crystal structure of 3-aminopropan-1-aminium iodide, C3H11N2I, Z. Krist – New Cryst. St. vol. 232, no 3, 477 – 478.
Arderne, C., Guzei, I. A., Holzapfel, C. W., Bredenkamp, T. 2016, Branched selectivity in the Pd-catalysed methoxycarbonylation of 1-alkenes, ChemCatChem. vol. 8, 1084 – 1093.
Guzei, I. A. & Arderne, C. 2015, Polymorphism of dinitro[tris(2-aminoethyl)amine]cobalt(III) chloride, Acta Cryst. Section C, vol. 71, no. 8, 695 – 700.
Arderne, C., Olivier, D. K., Ndinteh, D. T. 2015, Charge-assisted hydrogen bonding in salts of 2-amino-1H-benzimidazole with 3-phenylpropynoic acid and oct-2-ynoic acid, Acta Cryst. Section C, vol. 71, no. 2, 146 – 151.
Arderne, C. 2013, Pentane-1,5-diaminium dibromide, Acta Cryst. Section C, vol. 69, no. 5, 526 – 528.
Arderne, C. & Holzapfel, C. W. 2012, (Acetato-k2-O,O’)-(2′-di-t-butylphosphanyl)-1,1′-biphenyl-k2-P,C2)palladium(II), Acta Cryst. Section E, vol. 68, no. 8, m1308.
Arderne, C. & Holzapfel, C. W. 2012, Bis[(1,1′-biphenyl-2,2′-diyl)di-tert-butylphosphonium]di-m-chlorido-bis[dichloridopalladate(II)], Acta Cryst. Section E, vol. 68, no. 8, m1247.
Arderne, C. 2011, Heptane-1,7-diaminium dinitrate, Acta Cryst. Section E, vol. 67, no. 10, o3007.
Arderne, C. 2011, Decane-1,10-diaminium dinitrate, Acta Cryst. Section E, vol. 67, no. 10, o3008.
Arderne, C. 2011, Heptane-1,7-diaminium sulfate hydrate, Acta Cryst. Section E, vol. 67, no. 8, o2183.
Chiririwa, H., Meijboom, R., Owalude, S. O., Eke, U. B. and Arderne, C. 2011, Bis(acetonitrile – k -N)dichloride (h4-cycloocta-1,5-diene) ruthenium(II) acetonitrile monosolvate, Acta Cryst. Section E, vol. 67, no. 8, m1096.
Arderne, C. & Kruger, G. J. 2011, Butane-1,4-diammonium bis(perchlorate), Acta Cryst. Section E, vol. 67, no. 5, o1060.
Arderne, C. & Kruger, G. J. 2010, Ethane-1,2-diammonium dibromide – a redetermination at 100K, Acta Cryst. Section E, vol. 66, no. 9, o2470.
van Blerk, C. & Holzapfel, C. W. 2009, trans-Bis[bis(2-methoxyphenyl)phenylphosphine-kP] dichlorido-palladium(II), Acta Cryst. Section E, vol. 65, m1341.
van Blerk, C. & Holzapfel, C. W. 2009, trans-Dichloridobis[tris(2-methoxyphenyl) phosphine] palladium(II), Acta Cryst. Section E, vol. 65, m1342.
van Blerk, C. & Holzapfel, C. W. 2009, trans-Dichloridobis[tris(4-methoxyphenyl) phosphine] palladium(II) benzene monosolvate, Acta Cryst Section E, vol. 65, m1536.
van Blerk, C. & Kruger, G. J. 2009, Hexane-1,6-diammonium dinitrate, Acta Cryst. Section E, vol. 65, no. 5, o1008.
van Blerk, C. & Kruger, G. J. 2008, Hydrogen-bonding motifs and thermotropic polymorphism in redetermined halide salts of hexamethylenediamine, Acta Cryst. Section C, vol. 64, o537 – o542.
van Blerk, C. & Kruger, G.J. 2008, Synthesis and Structural Characterization of Butane-1,4-diammonium sulphate, Journal of Chemical Crystallography, vol. 38, 175 – 179.
van Blerk, C. & Kruger, G.J. 2007, Octane-1,8-diammonium dichloride monohydrate, Acta Cryst. Section E, vol. 63, no. 11, o4289.
van Blerk, C. & Kruger, G.J. 2007, Butane-1,4-diammonium dibromide, Acta Cryst. Section E, vol. 63, no. 1, o342-o344.
EXTRACURRICULAR ACTIVITIES:
I am an ex-South African figure skater and International judge for figure skating. I enjoy the outdoors – camping, running, going to the gym, walking, and hiking. I also enjoy reading, calligraphy, ceramic, and fabric painting and watching movies in the spare time that I have.