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Dr Charmaine Arderne

Dr Charmaine Arderne
Department of Chemistry
Senior Lecturer

Contact Details
C2 Lab 215
+27 (0) 11 559 2360
APK

POSTAL ADDRESS:
Department of Chemistry 
University of Johannesburg
PO Box 524
AUCKLAND PARK 2006
South Africa

 

PHYSICAL ADDRESS:
Room: C2LAB 215
Department of Chemistry
University of Johannesburg
Ditton Road
AUCKLAND PARK 
South Africa


ACADEMIC QUALIFICATIONS:

PhD (Physical Chemistry), University of Johannesburg, 2011


TEACHING RESPONSIBILITIES:

CEM1A10 – Introduction to General Chemistry

This module focuses on General Chemistry and aims to develop the students' knowledge and comprehension of chemical principles and techniques within general chemistry which will serve as a fundamental basis for further studies in the physical and biological sciences and in engineering. Additionally, the module aims to develop the technical abilities of the student through practical experience in the laboratory. 

CEM1B01 – Introduction to Physical and Organic Chemistry

This module focuses on Physical and Organic Chemistry with the following basic goals: To introduce students to the concepts of thermochemistry, thermodynamics, basic kinetics (zero and first order reactions), solution chemistry and electrochemistry in relation to technological advancement; to develop the students' understanding of foundational organic chemistry, introducing the student to synthesis and the importance of organic compounds in living systems. The student acquires an appreciation of functional group transformations and stereochemistry. Introductory laboratory skills are imparted to the student via experiments involving some synthesis and comparative techniques.


RESEARCH INTERESTS:

I have completed my PhD in Physical Chemistry with Prof. Gert Kruger in January 2011. Research that was carried out involved the crystallographic study of long-chained materials. Focus was on the structural characteristics and physical properties of long-chained n-alkyl diammonium salts as they are precursors to layered inorganic-organic perovskite-type hybrids; they are bidentate ligands in transition metal complexes that have applications in propellants, explosives and pyrotechnic compositions; they have structure directing properties in the synthesis of several zeolites and many new novel nanomaterials; and many have biological applications. Funding for the project came from the NRF Thuthuka programme and the University of Johannesburg.

I am currently a member of the Research Centre for Synthesis and Catalysis and am working on the following projects:

1. Metal induced cleavage of peptide and amide bonds using Co(III) amine and Co(III) amino acid complexes and their investigation as urease mimics.

This project is an experimental study of the synthesis, analysis and reaction of cobalt(III) amine and cobalt(III) amino acids complexes with urea-based materials to establish if cleavage of the amide and peptide bonds is successful. Also, the research is undertaken to determine and understand the mechanistic steps of these reactions and to conclusively determine if the cleavage occurs hydrolytically or by oxidative means and to establish if the metal complexes will function effectively as urease mimics. The broader scope of this project is in the field of biocatalysis. This project was awarded an NRF Thuthuka Award for funding 2016 – 2018. I have a small research group consisting of one MSc student; one PhD student and two Honours students, learning the relevant skills associated with this field of study. Recently, a postdoctoral fellow has joined the research group (Dr Bhawna Uprety) who will drive the project in a few different directions and she will also assist the current students with their research in this area. This work is a joint collaborative effort between myself and the project initiator Prof Ivan Bernal (retired Professor at University of Houston, Texas, USA) and Prof Demetrius Levendis (University of the Witwatersrand).

2. Structural investigation of natural products and their application in the field of medicinal chemistry.

This project is a structural study of several natural and synthetic materials that are tested for medicinal properties. The research undertaken involves the structural characterization using X-ray crystallography of many active ingredients that have been extracted from medicinal plants. Their structural characteristics are being investigated to understand their medicinal activity. This project is a collaboration within the Department of Chemistry on the APK campus and on the DFC campus (with Prof Derek Ndinteh, who is the project leader) and my role in the project is solely as a crystallographer. I also have an expert crystallographer collaborating on this project in the person of Prof Ilia Guzei (Visiting Professor, University of Johannesburg; University of Wisconsin – Madison) who assists with the solution of difficult crystal structures of the materials that are extracted from the plant material under investigation.

3. Collaborating Crystallographer for NWU – Mafikeng Campus.

In 2017, I was approached by Prof Damian Onwudiwe at NWU – Mafikeng Campus to assist him with X-ray crystallography for his research group. My role in his research is also solely as collaborating crystallographer.


RESEARCH COLLABORATIONS.

Prof Derek Ndinteh – University of Johannesburg (DFC Campus), RSA

Prof Ilia Guzei – University of Wisconsin, Madison, United States of America

Prof Ivan Bernal – University of Houston, Texas, United States of America

Prof Demetrius Levendis – University of the Witwatersrand, Johannesburg, RSA

Prof Damian Onwudiwer – North West University (Mafikeng Campus), RSA


RESEARCH PUBLICATIONS:

Ikhile, M. I., Fotsing, M. C. D., Arderne, C., Ngila, J. C. & Ndinteh, D. T. 2017, Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde, J. Chin. Pharm. Sci., vol. 16, no. 12, 858 – 871.

Vinokur, A. I., White, P. B., Fotsing, M. T., Arderne, C., Ndinteh, D. T., Vestling, M. M. & Guzei, I. A. 2017, Deciphering composition and connectivity of a natural product with the assistance of MS and 2D NMR, Acta Cryst. Section C, vol. 73, 994 - 1002.

Onwudiwe, D. C., Hrubaru, M., Hosten, E. C., Arderne, C. 2017, Bis(μ-N,N-diallyldithiocarbam-ato)bis[(N,N-diallyldithiocarbamato)cadmium], Acta Cryst. Section E, vol. 73, no. 9, 1353 – 1356.

Arderne, C., Batchelor, K. F. 2017, The crystal structure of 3-aminopropan-1-aminium iodide, C3H11N2I, Z. Krist - New Cryst. St. vol. 232, no 3, 477 – 478.

Arderne, C., Guzei, I. A., Holzapfel, C. W., Bredenkamp, T. 2016, Branched selectivity in the Pd-catalysed methoxycarbonylation of 1-alkenes, ChemCatChem. vol. 8, 1084 – 1093.

Guzei, I. A. & Arderne, C. 2015, Polymorphism of dinitro[tris(2-aminoethyl)amine]cobalt(III) chloride, Acta Cryst. Section C, vol. 71, no. 8, 695 – 700.

Arderne, C., Olivier, D. K., Ndinteh, D. T. 2015, Charge-assisted hydrogen bonding in salts of 2-amino-1H-benzimidazole with 3-phenylpropynoic acid and oct-2-ynoic acid, Acta Cryst. Section C, vol. 71, no. 2, 146 – 151.

Arderne, C. 2013, Pentane-1,5-diaminium dibromide, Acta Cryst. Section C, vol. 69, no. 5, 526 – 528.

Arderne, C. & Holzapfel, C. W. 2012, (Acetato-k2-O,O')-(2'-di-t-butylphosphanyl)-1,1'-biphenyl-k2-P,C2)palladium(II), Acta Cryst. Section E, vol. 68, no. 8, m1308

Arderne, C. & Holzapfel, C. W. 2012, Bis[(1,1'-biphenyl-2,2'-diyl)di-tert-butylphosphonium]di-m-chlorido-bis[dichloridopalladate(II)], Acta Cryst. Section E, vol. 68, no. 8, m1247.

Arderne, C. 2011, Heptane-1,7-diaminium dinitrate, Acta Cryst. Section E, vol. 67, no. 10, o3007.

Arderne, C. 2011, Decane-1,10-diaminium dinitrate, Acta Cryst. Section E, vol. 67, no. 10, o3008.

Arderne, C. 2011, Heptane-1,7-diaminium sulfate hydrate, Acta Cryst. Section E, vol. 67, no. 8, o2183.

Chiririwa, H., Meijboom, R., Owalude, S. O., Eke, U. B. and Arderne, C. 2011, Bis(acetonitrile - k -N)dichloride (h4-cycloocta-1,5-diene) ruthenium(II) acetonitrile monosolvate,  Acta Cryst. Section E, vol. 67, no. 8, m1096.

Arderne, C. & Kruger, G. J. 2011, Butane-1,4-diammonium bis(perchlorate), Acta Cryst. Section E, vol. 67, no. 5, o1060.

Arderne, C. & Kruger, G. J. 2010, Ethane-1,2-diammonium dibromide – a redetermination at 100K, Acta Cryst. Section E, vol. 66, no. 9, o2470.

van Blerk, C. & Holzapfel, C. W. 2009, trans-Bis[bis(2-methoxyphenyl)phenylphosphine-kP] dichlorido-palladium(II), Acta Cryst. Section E, vol. 65, m1341.

van Blerk, C. & Holzapfel, C. W. 2009, trans-Dichloridobis[tris(2-methoxyphenyl) phosphine] palladium(II), Acta Cryst. Section E, vol. 65, m1342.

van Blerk, C. & Holzapfel, C. W. 2009, trans-Dichloridobis[tris(4-methoxyphenyl) phosphine] palladium(II) benzene monosolvate, Acta Cryst Section E, vol. 65, m1536.

van Blerk, C. & Kruger, G. J. 2009, Hexane-1,6-diammonium dinitrate, Acta Cryst. Section E, vol. 65, no. 5, o1008.

van Blerk, C. & Kruger, G. J. 2008, Hydrogen-bonding motifs and thermotropic polymorphism in redetermined halide salts of hexamethylenediamine, Acta Cryst. Section C, vol. 64, o537 – o542.

van Blerk, C. & Kruger, G.J. 2008, Synthesis and Structural Characterization of Butane-1,4-diammonium sulphate, Journal of Chemical Crystallography, vol. 38, 175 – 179.

van Blerk, C. & Kruger, G.J. 2007, Octane-1,8-diammonium dichloride monohydrate, Acta Cryst. Section E, vol. 63, no. 11, o4289.

van Blerk, C. & Kruger, G.J. 2007, Butane-1,4-diammonium dibromide, Acta Cryst. Section E, vol. 63, no. 1, o342-o344.


For a link to Dr Arderne's CV please click here